Rare primary malignant melanoma of the esophagus with gastric cardia adenocarcinoma: A case report.

ABSTRACT:

Rationale

This case report presents an unusually rare instance of primary malignant melanoma of the esophagus (PMME) occurring concurrently with gastric cardia adenocarcinoma. It emphasizes diagnostic pitfalls in amelanotic melanoma and provides evidence supporting the role of adjuvant radiotherapy in achieving prolonged disease-free survival for this aggressive malignancy.

Patient concerns

A 60-year-old male with chronic tobacco and alcohol use presented with a 2-week history of progressive dysphagia. Endoscopy identified an obstructive esophageal mass and a gastric cardia ulcer, initially misdiagnosed as poorly differentiated carcinomas due to the absence of melanin pigmentation.

Diagnoses

The patient received a diagnosis of PMME in conjunction with gastric cardia a

SUBMITTER: Zhou Y 

PROVIDER: S-EPMC12517885 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature