Lack of genetic correlation and causal association between specific gut microbiota and osteoporosis.

ABSTRACT: Several observational studies have reported the change in gut microbiota (GM) composition in individuals with osteoporosis (OP); however, the genetic correlation and causal association between GM and OP remain undetermined. Large-scale genome-wide association study summary analysis of GM from the MiBio-Gen consortium and OP from the UK Biobank were used for analysis. Bivariate linkage disequilibrium score regression was conducted to explore the genetic correlation between GM and OP. Bidirectional 2-sample Mendelian randomization (MR) studies were then used to determine the causal association between GM and OP. genome-wide association study summary analysis of OP from the FinnGen consortium was used to replicate the MR analysis. Colocalization analysis was used to validate the suggestive as

SUBMITTER: Chen D 

PROVIDER: S-EPMC12517887 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature