M6A RNA methylation regulator heterogeneous nuclear ribonucleoprotein C: A prognostic biomarker for invasive ductal carcinoma validated through Mendelian randomization and transcriptome analyses.

ABSTRACT: Although aberrant N6-methyladenosine (m6A) RNA methylation has been linked to oncogenesis and tumor progression, the association between the deregulation of m6A regulators and invasive ductal carcinoma (IDC), the predominant subtype of breast cancer, remains unclear. In this study, we sought to determine the function of m6A RNA methylation regulators in IDC, with a particular focus on assessing their potential as prognostic biomarkers. To identify dysregulated m6A RNA methylation regulators, we systematically analyzed 656 samples from patients with IDC and 81 normal samples from The Cancer Genome Atlas (TCGA) database, and Cox univariate, LASSO-Cox regression, and stepwise regression analyses were conducted to construct a risk-prediction model for determining patient prognosis. Subsequentl

SUBMITTER: Wang Y 

PROVIDER: S-EPMC12517901 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature