The causal relationship between vitamin D deficiency and chronic hepatitis: A 2-sample Mendelian randomization approach.

ABSTRACT: Observational studies have suggested an association between vitamin D (Vit D) and chronic hepatitis (CH). However, the nature of this relationship remains uncertain. Therefore, the aim of this study is to investigate the potential causal links and specific directions between Vit D deficiency and CH. Gaining insights into the potential cause-and-effect association between Vit D deficiency and CH is crucial for understanding the disease progression and developing innovative strategies for the prevention and management of CH, as well as its associated complications. We employed a bidirectional 2-sample Mendelian randomization design to investigate the causal relationship between Vit D and CH, specifically chronic hepatitis B (CHB) and chronic hepatitis C (CHC). The exposure variables of inter

SUBMITTER: Li T 

PROVIDER: S-EPMC12517905 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature