Causal relationship between asthma and chronic rhinosinusitis: A Mendelian randomization study.

ABSTRACT: Observational studies have shown an association between asthma and chronic rhinosinusitis (CRS), but the exact causal relationship has not been clarified. This study aimed to deeply explore the causal relationship between asthma and CRS by using a 2-sample bidirectional Mendelian randomization (MR) method. This study used a 2-sample MR method, utilizing genome-wide association study data on asthma from the UKB database with a sample of 56,167 asthma patients and 3,52,255 controls, and CRS genome-wide association study data from the FinnGen database with a total of 8524 CRS patients and 1,67,849 controls. We conducted causal analyses through the inverse-variance weighting method, MR-Egger method, weighted median method, and weighted mode method, applied Cochrane's Q test for heterogeneity,

SUBMITTER: Li J 

PROVIDER: S-EPMC12517928 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature