Detection of Colistin Heteroresistance in Carbapenem-Resistant <i>Pseudomonas aeruginosa</i> Clinical Isolates in Iran.

ABSTRACT:

Background

Since antimicrobial resistance is a rising danger and a serious threat to the health of humans, recent studies have revealed that routine tests, such as minimum inhibitory concentration (MIC), are not enough to detect heteroresistance (HR) phenotype (i.e., phenotypic heterogeneity in antibiotic susceptibility in the identical bacterial population), and medical laboratories require awareness raising to face it. Colistin is regarded as the final therapeutic option for infections caused by carbapenem-resistant gram-negative bacteria. In this study, we explored the presence of HR to colistin in carbapenem-resistant Pseudomonas aeruginosa isolates in Iran.

Methods

From 2019 to 2020, 100 P. aeruginosa clinical isolates were gathered from hospitals in vario

SUBMITTER: Rad ZR 

PROVIDER: S-EPMC12517994 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature