Cs₂CO₃-N,N-Dimethylacetamide-Promoted Esterification of Arylformic Acids with a-Bromo Esters via Nucleophilic Substitution.

ABSTRACT: Herein, a nucleophilic substitution reaction between arylformic acids and α-bromo esters, facilitated by a Cs₂CO₃-DMA system, is reported. This reaction occurs under mild conditions, yielding a diverse range of valuable lactic acid derivatives (34 examples) with good to excellent yields (up to 97%). Subtle factors, such as the ion-dipole interactions between Cs₂CO₃, the substrates, and the solvent, may significantly influence the dynamics of the S_N2 reaction.

SUBMITTER: Song X 

PROVIDER: S-EPMC12518028 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature