β-Cyclodextrin Inclusion Complexes with Model Pentapeptides: Role of the Tyrosine Position within the Peptide Chain.

ABSTRACT: Peptide's applications frequently present problems of solubility, stability, activity, or membrane permeability. To overcome these issues, cyclodextrins (CDs) can be used to form inclusion complexes with peptide hydrophobic parts; alkyl-chains or aromatic-rings inclusion strongly influences the interacting peptide properties. The study of model tripeptides has revealed that, among the three aromatic amino acids, tyrosine is the best suited to be included within CDs. The interaction with β-CD of five model peptides (Tyr1-5), each constituted by one tyrosine and four alanines, is reported: the tyrosine occupies one of the five position within each peptide chain. Among natural CDs, β-CD has been chosen as it is the most economic, used, and only moderately toxic; its cavity size is the best su

SUBMITTER: Dragone M 

PROVIDER: S-EPMC12518031 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature