Synthesis of Fe₃O₄@Au Core-Shell Nanoparticles with Varying Thicknesses for Application in Computed Tomography Imaging.

ABSTRACT: To enhance the resolution of medical images, core-shell Fe₃O₄@Au hybrid nanoparticles (HNPs) with gold shells of varying thicknesses are developed. By optimizing synthesis conditions, nanoparticles with uniform size, clear core-shell structure, and high stability in biological environments are obtained. In vitro testing data shows that HNPs with a 5-7 nm-thick gold shell exhibits a high X-ray attenuation. The in vivo efficacy of the Fe₃O₄@Au HNPs is tested in liver and kidney tissues in a mouse model for study on drug kinetics. Results demonstrate the effectiveness of Fe₃O₄@Au HNPs in enhancing the contrast of computed tomography (CT) images, especially in the liver. Simultaneously, the clearance process of nanoparticles thr

SUBMITTER: Linh NTN 

PROVIDER: S-EPMC12518033 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature