Design, Synthesis, Biological Evaluation, and In Silico Study of Tetrahydropyridines as Prospective Monoamine Oxidase Inhibitors.

ABSTRACT: The potentiality of monoamine oxidase (MAO) enzymes to break monoamine neurotransmitters makes them efficacious druggable targets. Molecules having MAO-A inhibition characteristics are utilized as antidepressants while molecules with MAO-B inhibition prospective are utilized to treat Parkinson's and Alzheimer's diseases. Herein, we have shown how the selective inhibition of both isozymes can be attained by varying the substitution of electron-withdrawing and donating groups on the phenyl rings of tetrahydropyridines, i. e., ethyl 1,2,6-triaryl-4-(arylamino)-1,2,5,6-tetrahydropyridine-3-carboxylate (4 a-4 o). The structures of these piperidines (4 a-4 o) were unambiguously established by different spectro-analytical techniques, including ¹H- and ¹³C-NMR. Among the synt

SUBMITTER: Khan OUR 

PROVIDER: S-EPMC12518037 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature