Putative mutations associated with tetracycline resistance detected in Treponema spp.: an analysis of 4,355 Spirochaetales genomes.

ABSTRACT: The resurgence of syphilis has necessitated novel prophylactic strategies, such as the use of doxycycline post-exposure prophylaxis. However, the potential for increased doxycycline use to select for tetracycline resistance represents significant challenges in managing this sexually transmitted infection. This study aims to identify chromosomal mutations associated with tetracycline resistance in Spirochaetales to inform molecular surveillance tools. Whole-genome sequences (WGSs) from the Spirochaetales order, including 4,355 genomes, were analysed for the presence of mutations in 16S rRNA and non-synonymous mutations in the rpsC and rpsJ genes. The study utilized WGS from GenBank® and sequence data from the PubMLST Treponema pallidum isolate collection.

SUBMITTER: Manoharan-Basil SS 

PROVIDER: S-EPMC12518048 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature