Study on cerebrospinal fluid meropenem, vancomycin and tigecycline monitoring in patients with central nervous system infection following neurosurgery under different drug regimens.

ABSTRACT:

Introduction

Central nervous system infection (CNSI) following neurosurgery is challenging to treat and carries a high risk of recurrence, morbidity, and mortality. Low CNS penetration of antibiotics may contribute to poor clinical outcomes from CNS infections. Different drug regimens also suggested variable impacts on clinical outcomes. This study aims to measure the cerebrospinal fluid (CSF) concentration of meropenem, vancomycin and tigecycline in patients with CNSI following neurosurgery and thus evaluate the differential therapeutic efficacy of different drug regimens.

Methods

Patients who received meropenem, vancomycin and/or tigecycline for highly suspected or confirmed bacterial CNSI following neurosurgery were recruited from a tertiary hospital in Shanxi from Januar

SUBMITTER: Zhao X 

PROVIDER: S-EPMC12518061 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature