Differentiation of acute versus chronic skin rejection in a rodent model of vascularized composite allotransplantation.

ABSTRACT:

Background

Vascularized composite allografts (VCA) have evolved to be a potential option in complex reconstructive surgery. However, managing acute and chronic allograft rejection remains challenging. This study underlines differences between acute and chronic rejection in skin based on Banff criteria using rodent VCA models, enhancing comprehension of the underlying immunopathology.

Methods

We compared whole tissue sections of fresh frozen skin from a rat hindlimb allograft transplantation model of acute and chronic rejection, respectively (n=7), stained with Hematoxylin Eosin-, Periodic Acid Schiff- and Masson's Trichrome. Assessment followed the Banff 2007 working classification of skin-containing composite tissue allograft pathology, also considering the Banff 2022 VCA W

SUBMITTER: Thome J 

PROVIDER: S-EPMC12518069 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature