Penehyclidine in prevention of postoperative nausea and vomiting: a systematic review and meta-analysis of randomized controlled trials.

ABSTRACT:

Background

Postoperative nausea and vomiting (PONV) are prevalent complications following general anesthesia. The effectiveness of penehyclidine (PHC) in reducing PONV is still debated. To address this issue, we conducted this systematic review and meta-analysis to assess both the effectiveness and safety of PHC in preventing PONV after general anesthesia.

Methods

To gather relevant studies on PHC use for preventing PONV, six electronic databases (PubMed, Embase, Cochrane Library, Web of Science, China National Knowledge Infrastructure, and Wanfang Database) and trial registries were searched. Placebo-controlled trials that explored the effect of PHC on PONV in patients undergoing general anesthesia were included. The primary outcome was the incidence of PONV. Adverse events

SUBMITTER: Lu JC 

PROVIDER: S-EPMC12518294 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature