Killing two birds with one stone: emergence of colistin and cefiderocol resistance in a mucoid MDR <i>Acinetobacter baumannii</i> under colistin pressure.

ABSTRACT: Acinetobacter baumannii is a multidrug-resistant (MDR) pathogen associated with nosocomial infections, sporadically detected in cystic fibrosis (CF) patients. Treatment of A. baumannii may be hindered by polysaccharide capsule production of some isolates and extended resistance to most antibiotics. In these fearsome cases, colistin (COL) and cefiderocol (FDC) are considered last resort antibiotics. Unfortunately, resistance to these molecules is increasing. Indeed, we observed a hypermucoid (HM) A. baumannii strain producing OXA-23, isolated from a CF patient, rapidly evolving concomitant resistance to COL and FDC. At her first visit to our hospital, the 24-year-old female with a delayed CF diagnosis and advanced lung disease presented with one HM and one low mucoid (L

SUBMITTER: Fox V 

PROVIDER: S-EPMC12518295 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature