Effect of a luteal phase rescue protocol on live birth rates in frozen embryo transfer cycles.

ABSTRACT:

Introduction

Frozen embryo transfer (FET) is a standard procedure that improves live birth rates and reduces ovarian hyperstimulation risks. Optimizing luteal phase support with hormone replacement therapy (HRT), particularly by progesterone supplementation, enhances endometrial receptivity and embryo implantation success. Despite advances in cryopreservation techniques, optimal protocols for progesterone supplementation in HRT-FET cycles remain uncertain. This study aims to evaluate the effects of an individualized luteal phase protocol using subcutaneous progesterone on live birth rates in HRT-FET cycles.

Methods

In this retrospective cohort study, we analyzed data from 433 autologous FET cycles prepared with HRT. Serum progesterone levels were measured the day before FET.

SUBMITTER: Yazbeck C 

PROVIDER: S-EPMC12518300 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature