Shrunken pore syndrome in relation to morbidity and mortality in the population-based Malmo Diet and Cancer cohort: a generalized propensity score approach.

ABSTRACT:

Purpose

Glomerular filtration rate (GFR) is used for evaluating kidney function. Creatinine and cystatin C levels are the two endogenous substances used to estimate GFR (eGFR_CR and eGFR_CYS). The agreement between these two is reflected by the eGFR_CYS/eGFR_CR ratio. An eGFR_CYS/eGFR_CR ratio <0.70 has been strongly associated with mortality and morbidity. An explanation is a selective decrease in the filtration of substances of different masses, and this condition is referred to as "Shrunken pore syndrome" (SPS). We aim to investigate the prevalence of SPS and its association with morbidity and mortality in a well-characterized population-based cohort.

Methods

The study population consisted of 5,061 individuals fr

SUBMITTER: Akesson A 

PROVIDER: S-EPMC12518306 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature