Parkin overexpression modulates gut-microbiota composition during aging in <i>Drosophila melanogaster</i>.

ABSTRACT:

Background

The gut microbiota plays a key role in host health during aging, influencing metabolism, immune function, and lifespan. In older individuals, the microbial community often becomes less diverse and more unstable, which can contribute to chronic inflammation and increased disease risk. Parkin, an E3 ubiquitin ligase, is known to extend lifespan when overexpressed in Drosophila melanogaster, but it's still unclear whether it also influences the gut microbiota during aging and whether this might contribute to its longevity effects.

Methods

To investigate this, we used an inducible genetic system to overexpress Parkin in adult D. melanogaster. Midguts were collected at four time points: days 10, 30, 45, and 60, and bacterial DNA was extracted for 16S rRNA

SUBMITTER: Sarghie L 

PROVIDER: S-EPMC12518341 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature