Differential regulation of gene co-expression modules in muscles and liver of preterm newborns.

ABSTRACT:

Background

Newborns undergo rapid metabolic and organ adaptations after birth, which are compromised in premature newborns, leading to adverse health outcomes. Molecular mechanisms underlying these transitions remain poorly understood due to limited tissue availability. To address this gap, we characterized tissue transcriptomes using autopsy samples from a unique newborn cohort.

Methods

We analyzed liver (LI), heart (HM), and skeletal muscle (SM) transcriptomes using RNA sequencing in 41 predominantly premature newborns who died shortly after birth. Nearly 14,000 protein-coding gene transcripts per tissue were detected.

Results

Tissues exhibited distinct expression profiles, with LI showed the highest number of tissue-specific genes. SM gene expression correlated str

SUBMITTER: Janovska P 

PROVIDER: S-EPMC12518348 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature