NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), and SII (systemic immune-inflammation index) reflect disease activity and renal remission in patients with lupus nephritis.

ABSTRACT:

Objective

To evaluate the value of NLR (neutrophil to lymphocyte ratio), PLR (platelet to lymphocyte ratio), and SII (systemic immune-inflammation index) in reflecting disease activity and induction therapy remission in patients with lupus nephritis (LN).

Methods

Active LN patients from STAR cohort were enrolled. We analyzed the trends of complete blood count parameters with Generalized Estimated Equation. Bivariate correlation analyses, Chi-square tests, t-tests and logistic regression were employed to assess variable associations and identify prognostic factors for LN remission.

Results

310 active LN patients were enrolled in the study. All patients had active lupus with SLEDAI-2K 17.1 ± 6.1, median 24h-Urine Protein (UTP) level of 3.1 (1.5, 5.4) g. During th

SUBMITTER: Zhang X 

PROVIDER: S-EPMC12518351 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature