Molecular epidemiology and antimicrobial resistance profiles of <i>Pseudomonas aeruginosa</i> causing bloodstream infections in neutropenic cancer patients.

ABSTRACT:

Background

Bloodstream infections (BSI) in neutropenic cancer patients, particularly those caused by Pseudomonas aeruginosa (PA), are associated with high morbidity and mortality. The increasing prevalence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) PA strains complicates clinical management. This study aimed to characterise PA strains causing BSI in neutropenic cancer patients and assess the association between microbiological features and clinical outcomes.

Methods

We analysed PA strains from 94 BSI episodes in neutropenic cancer patients across five Spanish hospitals (2006-2018). Antimicrobial resistance, alginate and pigment production were assessed. Whole-genome sequencing was performed to identify resistance mutations and virulence genes.

SUBMITTER: Cadenas-Jimenez I 

PROVIDER: S-EPMC12518357 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature