Bone loss and increased bone marrow adiposity in ovary-intact and ovariectomized rats with chronic obstructive pulmonary disease.

ABSTRACT:

Objective

Osteoporosis is a major clinically significant extrapulmonary comorbidity that can arise in individuals with chronic obstructive pulmonary disease (COPD). While there have been reports of a negative correlation between bone marrow adiposity and bone integrity, the role of such adiposity in COPD-induced bone loss is not well understood. This study was developed with the aim of clarifying how COPD affects bone and bone marrow fat in both ovary-intact and ovariectomized (OVX) rats.

Methods

This study utilized 32 five-month-old female Wistar rats that either underwent bilateral OVX or Sham surgical procedures. Beginning 7 days after surgery, these rats were regularly exposed to cigarette smoke (CS) or room air (RA) for 5 months. At baseline, 3 months, and 5 months, a s

SUBMITTER: Fan J 

PROVIDER: S-EPMC12518374 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature