Pericardial adipose tissue promotes transition to heart failure with reduced ejection fraction upon pressure-overload in mice.

ABSTRACT: In patients, severity of pressure-induced heart failure (HF) due to aortic stenosis and metabolic disorder correlates with thickness and mass of epicardial adipose tissue (EAT). We examined the role of the less studied pericardial adipose tissue (PAT) during manifestation and progression of pressure-induced HF in mice. Progressive remodeling was assessed in C57BL/6 J males, aged 9 weeks, following sham surgery or transverse aortic constriction (TAC) for 1 week (early pressure-overload), 8 (chronic pressure-overload), or 12 weeks (HF with reduced ejection fraction, HFrEF) with or without concomitant PAT excision. PAT removal did not affect early (1-week TAC) or chronic (8 weeks) pressure-overload-induced concentric remodeling. However, initial PAT excision prevented lung congestion, progres

SUBMITTER: Shia YX 

PROVIDER: S-EPMC12518406 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature