Cerebellar large-scale network connectivity in Parkinson's disease: associations with emotion, cognition, and aging effects.

ABSTRACT: Emerging evidence highlights the cerebellum's involvement in Parkinson's disease (PD), yet its intrinsic functional connectivity with cortical-subcortical networks remains largely unexplored. This study aims to investigate cerebellar functional network alterations in PD and their associations with motor, cognitive, and emotional symptoms, as well as age-related effects. 82 participants with PD (PwPD) and 38 healthy controls (HCs) underwent structural and resting-state functional MRI scans. We conducted volumetric analysis in the cerebellum and examined the involvement of cerebellar functional networks in PD, both within-network and between-network connections regarding cortical-subcortical large-scale networks. Additionally, we explored correlations with motor, cognitive, and emotional sym

SUBMITTER: He C 

PROVIDER: S-EPMC12518413 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature