A Prospective Study to Determine Trimester-Specific Thyroid Function Reference Intervals.

ABSTRACT:

Purpose

Precise thyroid function assessment during pregnancy prevents inaccurate diagnosis of thyroid disease. This study aimed to establish trimester-specific reference intervals for thyroid function tests (TFTs) in Taiwanese pregnant women and analyze thyroid hormone and anti-thyroid antibody changes through gestation.

Methods

This prospective study at Taipei Veterans General Hospital (2019-2022) included 209 pregnant women. After excluding those with positive anti-thyroid antibodies, use of thyroid-related medications, or plans for abortion, 123 participants were eligible for thyroid function reference interval analysis. TFTs including thyroid-stimulating hormone (TSH), free T4, total T4, free T3, and total T3 along with antibodies were measured once per trimester using a

SUBMITTER: Pan LH 

PROVIDER: S-EPMC12518428 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature