Cortical volumetry and longitudinal cognitive changes in Parkinson's disease: insights from the COPPADIS cohort.

ABSTRACT: Cognitive decline is a major non-motor symptom in Parkinson's disease (PD), often linked to brain atrophy. This study examines the relationship between cortical atrophy and age groups in predicting cognitive decline in PD over five years. 188 PD patients from the COPPADIS cohort were stratified by age: young (30-55 years, N = 47), middle-aged (56-65 years, N = 59), and older adults (66-75 years, N = 82). Baseline cortical volume was assessed using T1-weighted MRI, and cognitive decline was evaluated using the annual rate of change of the Parkinson's Disease-Cognitive Rating Scale (PD-CRS). Parametric or non-parametric tests were applied to evaluate group differences. Main analyses consist of several multiple regression analyses to examine associations between baseline brain atrophy and cog

SUBMITTER: Alvarez-Avellon T 

PROVIDER: S-EPMC12518433 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature