Integrated analysis of gut microbiota, fecal and serum metabolites in type 2 diabetes mellitus with peripheral neuropathy.

ABSTRACT:

Purpose

Diabetic peripheral neuropathy (DPN) is one of the most common complications of type 2 diabetes mellitus (T2DM). In recent years, it has been reported that the progression of DPN is associated with altered gut microbiota and serum metabolites. However, the alterations of the gut microbiota and interaction with metabolites are not well understood in DPN patients. Therefore, we compared the gut microbiota and fecal and serum metabolic profiles of DPN and comprehensively analyzed the potential mechanisms of DPN.

Methods

A total of 50 patients were divided into two groups: T2DM group without DPN (T2DM group) and T2DM group with DPN (DPN group). Fecal and serum samples of all patients were collected, and serum metabolites were determined by ¹H-Nuclear Magnetic

SUBMITTER: Xu W 

PROVIDER: S-EPMC12518490 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature