Structural and diffusion imaging in olfactory-related brain regions in Parkinson's disease: predictors of clinical progression.

ABSTRACT: Olfactory dysfunction is a prevalent non-motor symptom in Parkinson's disease (PD). Structural and diffusion MRI studies suggest that olfactory-related brain regions undergo significant neurodegenerative changes in PD. The current study aims to explore the longitudinal structural and diffusion imaging in olfactory-related regions in PD over four years. The relationships between baseline imaging and fluid biomarkers, and subsequent cognitive and clinical changes were also explored. We analyzed 97 newly diagnosed early-stage PD patients from the Parkinson's Progression Markers Initiative (PPMI) who underwent T1-weighted MRI, diffusion tensor imaging (DTI), and clinical assessments at baseline, two years, and four years. Structural and diffusion measures of olfactory-related regions were extr

SUBMITTER: Hosseini SM 

PROVIDER: S-EPMC12518524 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature