Endometrial receptivity profiled through transcriptomic analysis of uterine fluid extracellular vesicles using systems biology and bayesian modeling for pregnancy prediction.

ABSTRACT: Identifying the optimal Window Of embryo Implantation (WOI) is important for improving pregnancy rates in Assisted Reproductive Technology (ART). During the WOI, the endometrium becomes receptive, enabling the complex communication between the embryo and endometrial tissue needed for the initiation of pregnancy. This study explores the molecular landscape of endometrial receptivity by analyzing the transcriptomic profile of Extracellular Vesicles isolated from Uterine Fluid (UF-EVs), a non-invasive alternative to traditional endometrial biopsies. RNA-sequencing of UF-EVs collected from 82 women undergoing ART with single euploid blastocyst transfer revealed 966 differentially 'expressed' genes (nominal p-value < 0.05) between women who achieved pregnancy (N = 37) and those who did not (N =

SUBMITTER: Marzanati D 

PROVIDER: S-EPMC12518540 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature