Chronic treatment with fluoxetine regulates mitochondrial features and plasticity-associated transcriptomic pathways in parvalbumin-positive interneurons of prefrontal cortex.

ABSTRACT: Chronic treatment with fluoxetine, a widely prescribed selective serotonin reuptake inhibitor (SSRI), is known to promote neural plasticity. The role of fluoxetine in plasticity has been particularly tied to parvalbumin-positive interneurons, a key population of GABAergic neurons that regulate inhibitory tone and network stability. While our previous studies have highlighted fluoxetine-induced plasticity in the visual cortex and hippocampus, its cell-type-specific effects in the prefrontal cortex (PFC) remain unclear. This study aims to investigate the effects of chronic fluoxetine treatment on PV-positive (PV⁺) cells, identified using PV-IRES-Cre-driven reporter expression in the PFC. Using Translating Ribosome Affinity Purification (TRAP), we found that fluoxetine treatment al

SUBMITTER: Jetsonen E 

PROVIDER: S-EPMC12518560 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature