Pathogenesis of thymoma-associated myasthenia gravis: a narrative review.

ABSTRACT:

Background and objective

Patients with thymomas often develop autoimmune neuromuscular diseases, including myasthenia gravis (MG). Autoantigen expression in thymomas plays an important role in disease pathogenesis. Since thymomas are mainly composed of the cortex, with few medullae, MG may be caused by immature thymoma-derived T cells that fail to undergo negative selection and have not yet acquired sufficient self-tolerance. However, due to the complexity and diversity of thymoma cell populations, a comprehensive understanding of the mechanisms underlying its association with MG has yet to be achieved. The purpose of this article is to provide an overview of the normal thymus function and the pathogenesis of thymoma associated with MG and other autoimmune diseases, with the aim to

SUBMITTER: Okuno T 

PROVIDER: S-EPMC12518592 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature