Influence of immune history when choosing a SARS-CoV-2 booster strategy.

ABSTRACT: Given the continued emergence of SARS-CoV-2 variants of concern as well as unprecedented vaccine development, it is crucial to understand the effect of updated vaccine formulations at the population level. While bivalent formulations developed during 2022 have had higher efficacy in vaccine trials, translating these findings to real-world effectiveness is challenging due to diversity in immune history, especially in settings with a high degree of natural immunity. Known socioeconomic disparities in key metrics such as vaccine coverage, social distancing, and access to healthcare have likely shaped the development and distribution of this immune landscape. Yet little has been done to investigate the impact of booster formulation in the context of host heterogeneity. Here, we present work un

SUBMITTER: Larsen SL 

PROVIDER: S-EPMC12518628 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature