Efficacy of Combined Versus Supplementary Injection Techniques With Inferior Alveolar Nerve Block for Mandibular Molars With Symptomatic Irreversible Pulpitis: A Systematic Review and Network Meta-Analysis.

ABSTRACT:

Background

Achieving effective anaesthesia in mandibular molars with symptomatic irreversible pulpitis is challenging. Various strategies involving the inferior alveolar nerve block (IANB) have been investigated, such as supplementing with additional injections after IANB failure (SUPP) or combining injections with IANB as primary injections (COMB). However, studies directly comparing SUPP and COMB are still lacking.

Objectives

This study aims to assess and compare the anaesthetic effectiveness of different IANB strategies-SUPP and COMB-in mandibular posterior teeth with symptomatic irreversible pulpitis using a systematic review and network meta-analysis.

Method

A comprehensive search was conducted in the PubMed, Embase, Cochrane Library, CINAHL and Scopus databases

SUBMITTER: Rujirawan T 

PROVIDER: S-EPMC12518700 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature