Dual redox effects of 2,6-bis-(4-hydroxyl-3-methoxybenzylidene) cyclohexanone (BHMC) on human liver cancer cells, HepG2 via ROS, glutathione and Nrf2/Keap1 pathway.

ABSTRACT:

Introduction

Curcumin has demonstrated significant potential as a chemoprotective agent by inducing death in malignant cells while exhibiting selective cytotoxicity toward normal cells. However, curcumin has limited bioavailability which hindered its full potential. Thus, 2,6-bis-(4-hydroxyl-3-methoxybenzylidene) cyclohexanone (BHMC), a curcuminoid derivative is produced by eliminating unstable β-diketone component, transformed it with double bonds while retaining the phenolic hydroxyl group. Of note, BHMC triggers greater cytotoxic effect via inducing higher oxidative stress damage through reactive oxygen species (ROS)-mediated pathway. Increased of ROS cause the redox buffering system to collapse, resulting in lipid peroxidation and disintegration of the mitochondrial membrane po

SUBMITTER: Mohd Shafiee MA 

PROVIDER: S-EPMC12518719 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature