PET imaging of mitochondrial complex-I in the adenine-induced tubulointerstitial nephropathy mouse model using [¹⁸F]BCPP-BF.

ABSTRACT:

Background

Chronic kidney disease (CKD) poses a significant global health burden with limited effective treatments for its prevention, progression, and associated complications. Mitochondrial dysfunction is recognized as a pivotal factor in the development of kidney diseases, with mitochondrial complex-I (MC-I) playing a crucial role in assessing overall mitochondrial function. Recent advancements in selective MC-I positron emission tomography (PET) radioligands now allow for non-invasive visualization and quantification of renal mitochondrial status in vivo. The aim of the present study was to evaluate the utility of [¹⁸F]BCPP-BF in the adenine induced tubulointerstitial nephropathy model.

Results

Binding of the MC-I targeted PET radioligand, [¹⁸F]BCPP

SUBMITTER: Dahl K 

PROVIDER: S-EPMC12518723 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature