Oncogenic EME1 promotes tumor progression and immune modulation in human cancers with therapeutic targeting potential.

ABSTRACT:

Background

EME1, a critical DNA repair endonuclease, has emerged as a potential oncogene implicated in genome instability and cancer progression. However, its pan-cancer roles, prognostic significance, immune interactions, and therapeutic targeting remain underexplored.

Methods

We conducted a comprehensive pan-cancer analysis integrating multi-omics data from public databases, including TIMER2.0, GEPIA2, TISIDB, and cBioPortal, to evaluate EME1 expression, genetic alterations, and their association with clinical outcomes, immune infiltration, and molecular pathways. Virtual screening of 3180 FDA-approved drugs and molecular dynamics (MD) simulations were employed to identify and validate potential EME1 inhibitors.

Results

EME1 was significantly overexpressed in variou

SUBMITTER: Eldeen MA 

PROVIDER: S-EPMC12518739 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature