HSF2BP modulates lung adenocarcinoma proliferation and immune microenvironment via BNC1/TGF-β/SMAD3 signaling pathway.

ABSTRACT: The tumor microenvironment plays a critical role in the progression and metastasis of lung adenocarcinoma (LUAD), characterized by its immunosuppressive nature. Identifying the mechanisms that contribute to the remodeling of this environment is essential for developing therapeutic strategies. Heat shock factor 2-binding protein (HSF2BP) is implicated in tumor proliferation and immune evasion, but the mechanisms by which HSF2BP exerts these effects remain poorly understood. This study investigates the role of HSF2BP in modulating Basonuclin 1 (BNC1) expression and subsequent immune responses in LUAD. Matched tumor and adjacent normal tissue samples from 30 LUAD patients were collected between January 2023 and June 2024. Using lentiviral transduction, HSF2BP and BNC1 were overexpressed or kn

SUBMITTER: Liu J 

PROVIDER: S-EPMC12518831 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature