The G1/S transition in mammalian stem cells in vivo is autonomously regulated by cell size.

ABSTRACT: Cell growth and division must be coordinated to maintain a stable cell size, but how this coordination is implemented in multicellular tissues remains unclear. In unicellular eukaryotes, autonomous cell size control mechanisms couple cell growth and division with little extracellular input. However, in multicellular tissues we do not know if autonomous cell size control mechanisms operate the same way or whether cell growth and cell cycle progression are separately controlled by cell-extrinsic signals. Here, we address this question by tracking single epidermal stem cells growing in the mouse ear. We find that a cell-autonomous size control mechanism, dependent on the RB pathway, sets the timing of S phase entry based on the cell's current size. Cell-extrinsic variations in the cellular mi

SUBMITTER: Xie S 

PROVIDER: S-EPMC12518844 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature