Mapping brain-wide activity networks: brainways as a tool for neurobiological discovery.

ABSTRACT: Identifying brain-wide neural circuits and targeting these areas for neuropharmacological interventions are significant challenges in contemporary neuroscience. Traditional methods for registering and quantifying fluorescence in brain slices are labor-intensive and struggle to extract functional insights from complex datasets. To address these challenges, we introduce Brainways-an AI-based, open-source software that streamlines neural network identification from digital imaging to network analysis. Brainways facilitates neurobiological research by enabling automatic registration of coronal brain slices to any 3D brain atlas, along with precise quantification of fluorescent markers, such as activity markers and tracers, across brain regions. Brainways incorporates advanced statistical tools

SUBMITTER: Kantor B 

PROVIDER: S-EPMC12518845 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature