Nobiletin (NOB) nanoparticles ameliorate chronic paradoxical sleep deprivation (PSD)-induced cognitive deficits in rats.

ABSTRACT: Nobiletin (NOB), a naturally occurring polymethoxyflavonoid, has been shown to regulate the expression of the clock gene BMAL1. This study aims to explore the impact of NOB nanoparticles on microglial polarization and cognitive impairments resulting from chronic sleep paradoxical deprivation (PSD), as well as the mechanisms involved. Following PSD modeling, rats treated with NOB nanoparticles exhibited significantly improved cognitive performance in behavioral tests. The treatment upregulated the expression of BMAL1, SIRT1, E2F1, and the NAD+/NADH ratio, shifted microglial polarization from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype, and enhanced antioxidant defenses. The NAD⁺ inhibitor apocynin and silencing of BMAL1 could reverse the effects of NOB

SUBMITTER: Hu Y 

PROVIDER: S-EPMC12518861 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature