Solid-phase microextraction of sweat components of patients positive for Sars-Cov-2 for identification of possible biomarkers.

ABSTRACT: Metabolomics is gaining consideration as a viable approach to diseases detection and even shows promising results in COVID-19 diagnosis. This work extends the study of the relationship between extractable sweat compounds and COVID-19 positive patients. Sweat samples were collected from 426 patients (126 positives and 300 negatives) recruited at Merida and Progreso (Yucatán, México) health centers. The composition of sweat was analyzed with a solid phase microextraction gas chromatography-mass spectrometry (SPME-GC-MS) method. The PLS-DA, with specificity and sensitivity percentages greater than 80%, revealed significant differences between the DI-SPME profiles of infected and non-infected patients. Six key peaks used in the classification model were annotated as undecanal, methyl palmitole

SUBMITTER: Soler-Jimenez LC 

PROVIDER: S-EPMC12518868 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature