Investigation of the toxicological effects of PFAS on cholangiocarcinoma based on network toxicology, bioinformatics, and molecular docking.

ABSTRACT: Previous studies have identified an association between per- and polyfluoroalkyl substances (PFAS) and the occurrence of intrahepatic cholangiocarcinoma (ICC), but the specific mechanisms remain unclear. This study aims to analyze the toxicological mechanisms of PFAS, particularly perfluoroctanoic acid (PFOA) and perfluorooctane sulfonate (), on ICC through network toxicology and bioinformatics. Relevant targets for PFOS and PFOA were retrieved from the CTD, ChEMBL, and Super-PRED databases. Targets related to ICC were gathered from the GeneCards, NCBI, and OMIM databases. Common targets between ICC and PFOS, PFOA were identified and subjected to median filtering in CytoHubba to select core targets, which were then analyzed for protein-protein interaction using the STRING database. Gene On

SUBMITTER: Sun H 

PROVIDER: S-EPMC12518873 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature