Tobacco Smoking Functional Networks: A Whole-Brain Connectome Analysis in 24 539 Individuals.

ABSTRACT:

Introduction

Nicotine addiction, a multifaceted neuropsychiatric disorder, profoundly impacts brain functions through interactions with neural pathways. Despite its significance, the impact of tobacco smoking on the whole-brain functional connectome remains largely unexplored.

Aims and methods

We conducted a whole-brain analysis on 24 539 adults aged 40 and above from the United Kingdom Biobank cohort. Subjects were categorized into individuals who use nicotine and those who do not use nicotine based on current and chronic tobacco smoking information. Functional connectivity was assessed using resting-state functional magnetic resonance imaging. We employed a network analysis method to assess the systematic effects of tobacco smoking on brain connectome by identifying subnet

SUBMITTER: Pan Y 

PROVIDER: S-EPMC12518922 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature