Association between metabolites and hepatocellular carcinoma: findings from a two-sample Mendelian randomization study.

ABSTRACT:

Backgrounds/aims

Identifying metabolic biomarkers can enhance early detection and risk stratification of hepatocellular carcinoma (HCC). We conducted a two-sample Mendelian randomization (MR) study to assess the potential causal effects of metabolites on HCC risk.

Methods

We performed meta-analyses to pool the effects of genetic instruments from 64 previously published genome-wide association studies. Summary statistics for HCC were obtained from a meta-analysis of the UK BioBank and FinnGen cohorts. MR analyses for the association between 3,275 metabolites and HCC risk were performed using inverse variance weighted, weighted median, MR-Egger, and MR-PRESSO methods to estimate the association. Enrichment analyses were performed on the significant metabolites to identify biol

SUBMITTER: Hoang T 

PROVIDER: S-EPMC12518980 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature