Investigating pharmacotherapies for alcohol use disorder using Drosophila melanogaster.

ABSTRACT:

Background

Drosophila melanogaster provides a powerful whole-organism approach for the therapeutic discovery of treatments for many disorders due to the ability to perform high-throughput drug studies with detailed molecular and cellular mechanisms. While Drosophila has been critical for identifying novel molecular and neural circuit mechanisms underlying alcohol responses, few studies assess the use of Drosophila for the investigation and discovery of pharmacological targets of alcohol use disorder (AUD). Determining appropriate doses that impact alcohol consumption and memory for alcohol reward without affecting acute locomotor responses is key to identifying effective AUD medications such as naltrexone, acamprosate, and topiramate. This pipeline can then be used to test novel ph

SUBMITTER: Oramas R 

PROVIDER: S-EPMC12519048 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature