Neuropeptide Y1 receptor expressing circuit from the central amygdala to lateral hypothalamus modulates binge-like ethanol consumption in a sex-dependent manner.

ABSTRACT:

Background

Alcohol use disorder is characterized by maladaptive patterns of alcohol consumption, with emerging evidence suggesting that neuropeptide Y (NPY) signaling through Y1 and Y2 receptors (Y1R and Y2R) within the central amygdala (CeA) plays a critical role in modulating ethanol intake. The current experiments investigate the neural mechanisms underlying binge-like ethanol drinking, focusing on the involvement of Y1R+ CeA-to-lateral hypothalamus (LH) projections, dynamic interactions between Y1R and Y2R within the CeA, and the impact of chronic ethanol exposure on Y1R protein expression.

Methods

NPY1R-ires-cre mice received LH cannulation, were infused with cre-dependent inhibitory (Gi) Designer Receptor Exclusively Activated by Designer Drug (DREADD) or control virus

SUBMITTER: Bendrath SC 

PROVIDER: S-EPMC12519052 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature