Within-host mathematical models to study antibody kinetics after the prophylactic Ebola vaccine in the Democratic Republic of the Congo.

ABSTRACT: Ebola virus disease remains a threat in different Sub-Saharan African countries more particularly in the Democratic Republic of Congo, where persistent outbreaks are driven by human populations living in close proximity to animal reservoirs. While vaccines like Ad26.ZEBOV and MVA-BN-Filo are safe and immunogenic, the dynamics of antibody responses after the two-dose regimen and booster vaccination are not fully understood. Within-host mathematical models offer valuable insights into disease dynamics and waning immunity, but data-driven mechanistic models of antibody kinetics remain scarce. The present study seeks to elucidate the processes involved in antibody kinetics after the two-dose vaccine regimen with Ad26.ZEBOV and MVA-BN-Filo vaccines, followed by a booster dose vaccination with A

SUBMITTER: Garcia-Fogeda I 

PROVIDER: S-EPMC12519101 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature