Global constraint principle for microbial growth laws.

ABSTRACT: Understanding complex living systems requires identifying universal phenomenological laws that are independent of species and molecular-biological details. The Monod equation is a cornerstone of phenomenological microbial growth laws, depicting the growth rate as a saturating function of a single substrate. Because of its similarity in functional form to the Michaelis-Menten equation, cellular growth is often thought to be limited by a single reaction. However, cellular growth generically results from the coordination of thousands of metabolic reactions and diverse intracellular limited resources. Consequently, the mechanistic origins of the Monod equation remain controversial, and its extension has encountered limitations. Here, we propose the global constraint principle for cellular grow

SUBMITTER: Yamagishi JF 

PROVIDER: S-EPMC12519149 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature