Isolated IgG elevation in patients with persistently normal transaminases does not affect the outcome of autoimmune hepatitis.

ABSTRACT:

Background & aims

The goal of treatment for autoimmune hepatitis is to achieve a complete biochemical response, defined as normalization of transaminases and immunoglobulin G (IgG) levels. Recent data suggest that IgG normalization does not significantly affect survival. We evaluated the impact of persistently elevated IgG levels (IgGe) and IgG flares (IgGf) on fibrosis progression and cirrhosis development.

Methods

This retrospective multicenter cohort study included 493 patients with autoimmune hepatitis and persistently normal transaminase levels during follow-up. The inverse probability of treatment weighting (IPTW) propensity score method was used to balance the cohorts.

Results

Three hundred forty-nine (70.8%) patients had persistently normal IgG (IgGn) levels,

SUBMITTER: Diaz-Gonzalez A 

PROVIDER: S-EPMC12519241 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature