Dephosphorylation of astrocyte elevated gene-1 protein upregulates eIF4E expression to promote gastric cancer progression.

ABSTRACT: Protein phosphorylation modification plays an important role in regulating protein activity. Astrocyte elevated gene-1 (AEG-1), an adaptor protein, promotes the progression of various types of cancers by protein-protein interactions. We previously demonstrated that AEG-1 promoted the growth and metastasis of gastric cancer by upregulating the expression of oncogenic eukaryotic translation initiation factor 4E. However, a role for AEG-1 phosphorylation is not known. In this study, we identified phosphorylation of serines 426 (S426) and 308 (S308) as the inactive status of AEG-1. Decreased AEG-1 S426 phosphorylation in human gastric cancer tissues was correlated with the cancer progression, whereas AEG-1 S426 dephosphorylation upregulated eukaryotic translation initiation factor 4E transcrip

SUBMITTER: Zhao L 

PROVIDER: S-EPMC12519287 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature